Table 2.
Summary of top hits in meta-analysis of serum iron GWAS.
| SNP | Nearest protein coding gene | Position (GRCh37) | Effect allele | Direction | Z score | Meta-analysis p value | MAF | Beta | SE |
|---|---|---|---|---|---|---|---|---|---|
| rs35945185 | LEPR | chr1:66,137,239 | A | ???+ | 7.384 | 1.54e−13 | 0.38 | 0.022 | 0.003 |
| rs4129267 | IL6R | chr1:154,426,264 | T | ++++ | 8.719 | 2.802e−18 | 0.36 | 0.025 | 0.003 |
| rs7580634 | IL1RN | chr2:113,866,854 | T | ?−−− | − 6.39 | 1.663e−10 | 0.42 | − 0.019 | 0.003 |
| rs6726348 | ILKAP | chr2:239,084,119 | T | ++−+ | 9.495 | 2.193e−21 | 0.45 | 0.026 | 0.003 |
| rs12633819 | LRIG1 | chr3:66,448,307 | A | −−+− | − 8.277 | 1.259e−16 | 0.36 | − 0.024 | 0.003 |
| rs8177252 | TF | chr3:133,480,174 | A | ++++ | 17.07 | 2.494e−65 | 0.35 | 0.049 | 0.003 |
| rs6583288 | TFRC | chr3:195,809,564 | A | −+−− | − 5.68 | 1.349e−08 | 0.26 | − 0.018 | 0.003 |
| rs7655524 | PDGFRA | chr4:55,354,337 | A | −−−− | − 5.746 | 9.131e−09 | 0.39 | − 0.016 | 0.003 |
| rs1800562 | HFE | chr6: 26,093,141 | A | ++++ | 41.442 | 2.23e−375 | 0.04 | 0.29 | 0.007 |
| rs7776054 | HBS1L | chr6:135,418,916 | A | −−−− | − 15.848 | 1.451e−56 | 0.26 | − 0.05 | 0.003 |
| rs6976036 | IKZF1 | chr7:50,429,442 | T | ?+−− | − 6.939 | 3.96e−12 | 0.5 | − 0.02 | 0.003 |
| rs2075672 | TFR2 | chr7:100,240,296 | A | −−−− | − 18.482 | 2.861e−76 | 0.38 | − 0.052 | 0.003 |
| rs7897379 | REEP3 | chr10:65,301,725 | T | −+−− | − 6.88 | 5.982e−12 | 0.49 | − 0.019 | 0.003 |
| rs4759827 | ADGRD1 | chr12:131,492,288 | T | ?+−− | − 5.59 | 2.276e−08 | 0.29 | − 0.018 | 0.003 |
| rs1958078 | SMOC1 | chr14:70,354,858 | A | −+−− | − 8.208 | 2.252e−16 | 0.17 | − 0.03 | 0.004 |
| rs28929474 | SERPINA1 | chr14:94,844,947 | T | ?−?+ | 7.635 | 2.256e−14 | 0.02 | 0.079 | 0.01 |
| rs1961660 | DUOX2 | chr15:45,401,636 | T | ?++− | − 5.644 | 1.658e−08 | 0.07 | − 0.032 | 0.006 |
| rs531019 | NEO1 | chr15:73,598,607 | A | −−+− | − 6.045 | 1.496e−09 | 0.47 | − 0.017 | 0.003 |
| rs77542162 | ABCA6 | chr17:67,081,278 | A | ?−+− | − 7.286 | 3.2e−13 | 0.01 | − 0.106 | 0.015 |
| rs34536858 | KRTDAP, FFAR2 | chr19:35,950,174 | A | ?+++ | 7.573 | 3.651e−14 | 0.29 | 0.024 | 0.003 |
| rs1800961 | HNF4A | chr20:43,042,364 | T | ?−−+ | 5.508 | 3.629e−08 | 0.04 | 0.041 | 0.007 |
| rs855791 | TMPRSS6 | chr22:37,462,936 | A | −−−− | − 41.443 | 2.17e−375 | 0.39 | − 0.116 | 0.003 |
| rs3747207 | PNPLA3 | chr22:44,324,855 | A | ?−++ | 7.129 | 1.012e−12 | 0.22 | 0.025 | 0.003 |
MAF minor allele frequency, from the 1000 Genomes European super-population, SE standard error of the Beta.
Direction of effect of the four input summary statistics corresponding to the following order: Benyamin et al. meta-analysis, Baltimore Longitudinal Study of Aging, Montreal Heart Institute Biobank, Moksnes et al. meta-analysis. The symbols −, + and ? in this column indicate that relative to the effect allele, there was a negative effect, a positive effect or the variant was not assessed, respectively in that particular dataset.