FIG. 3.

Neither ARV-176 nor ARV-138 differentially affects NO production by infected macrophages. HD-11 cell monolayers were incubated for 6 h in the presence (black bars) or absence (gray bars) of LPS at 500 ng/ml followed by infection with equivalent concentrations of QM5 focus-forming units of ARV-176 or ARV-138 per milliliter. At 12 hpi the supernatants were harvested and assayed for the presence of nitrite using standard protocols. Nitrite concentrations were determined relative to a standard sodium nitrite curve. Uninf., uninfected cells.