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ARV-138 is capable of complete infection of HD-11 macrophage monolayers. HD-11 macrophages were left uninfected (b) or were infected with increasing concentrations of standardized QM5 focus-forming units of ARV-176 (a) or ARV-138 (c) per milliliter. Monolayers were fixed and immunostained as described for Fig. 1 to reveal viral foci of infection. The ARV-138 inoculum in panel c corresponds to a 32-fold increase in the QM5 focus-forming units compared to the ARV-176 inoculum in panel a.
