Fig 4.

Association of the change in CSF fibrinogen with neuronal biomarkers. (a) The β coefficients using the change in CSF fibrinogen to predict CSF NfL, total tau, ptau, and AβR controlling for their baseline concentrations. (b) The β coefficients for CSF NfL, total tau, ptau, and AβR additionally adjusted for age. The coefficient point estimates and 95% confidence intervals are shown. One outlier was excluded based on Cook's distances in both models. Full details of these models are provided in Supplementary Table S6. AβR, amyloid beta ratio; CSF, cerebrospinal fluid; NfL, neurofilament light; ptau, phospho-tau.