Table 2.

Experimental Data and Parameters Used for Figure 6

Experimental data used in optimization
Mice		BA in SI (μmol)		BA in feces (μmol)		1o BA in SI			1o BA in feces
B6		215		9		88%			32%
B6.Slc10a2-/-		44		43		60%			14%

Parameters used in simulations (rates given in min-1)
$t_{si}$	$t_{il}$	$t_{co}$	$a_{act}$	$p_{si}$	$p_{co}$	$c_{co}$	$c_{wt}$	$c_{ko}$	$K_x$	$K_y$
0.1	0.05	0.01	0.29	0.025	0.0012	0.0030	0.0010	0.0090	1.20	4.29

BA, bile acid; SI, small intestine.