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Summary of screening results using the method described in this protocol
| PP1/PP2A target | Type of modulator | Compounds tested | Confirmed hits (hit rate) | Computed ligandability (P2Rank) |
|---|---|---|---|---|
| PP1:MYPT1-Ank | inhibition | 1,500 | 1 (0.07%) | 8.8 |
| PP1:Inhibitor-2 | inhibition | 1,500 | 0 (NA) | 3.2 |
| B56 (PP2A):LSPI-SliM | inhibition | 65,000 | 2 (0.003%) | 2.4 |
| PP1:SDS22 | inhibition | 65,000 | 0 (NA) | 0 |
| PP2A:B56 | stimulation | 500,000 | 3 (0.0006%) | 1.6 |
