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. 2024 Oct 2;42:100879. doi: 10.1016/j.bbih.2024.100879

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 7 — Exposure to an obesogenic diet and chronic psychosocial stress influence corticosterone levels and hippocampal Fkbp5 gene expression. (A) Fecal corticosterone metabolite (FCM) levels were significantly decreased by the WD (p = 0.0018). (B) We observed significant effects of WD (p = 0.0052), PSS (p = 0.0008), and their interaction (p = 0.039) following the first day after predatory exposure. PSS significantly increased FCM levels in the WD rats (p = 0.0012). (C) FCM remained significantly elevated in PSS rats 24 h after the second predatory exposure (p = 0.0250). (D) Hippocampal Fkbp5 mRNA levels were significantly decreased by the WD (p = 0.0016) and PSS (p = 0.020). RT-PCR: 3 rats/group.