Table 6.

Statistical Information of TNF-α gene expression, protein release and ROS in HCM3 cells following P A + CORT treatment. TNF-α gene expression was significantly affected by the interaction of PA + CORT (p = 0.0002) and by CORT treatment alone (p = 0.0146). TNF-α protein release was significantly affected by the interaction of P A + CORT (p = 0.0021) and by CORT (p = 0.0002) and P A (p = 0.0096). ROS was significantly influenced by the interaction of P A + CORT (p = 0.0459) and by CORT (p < 0.0001) and P A (p < 0.0001). Bold denotes significant effects following three-way ANOVA and post hoc comparisons. Sample size: gene and protein measurements: 3 rats/group; ROS: 4 rats/group.

	TNF-α	TNF-α	ROS
	Gene expression	Protein release	RFU
Source of Variation	F Statistic, post-hoc	F Statistic, post-hoc	F Statistic, post-hoc
CORT:PA	F (1, 11) = 30.84,	F (1, 12) = 15.19,	F (1, 12) = 4.957,
	p = 0.0002	p = 0.0021	p = 0.0459
CORT	F (1, 11) = 8.384,	F (1, 12) = 28.50,	F (1, 12) = 37.02,
	p = 0.0146	p = 0.0002	p < 0.0001
PA	F (1, 11) = 0.0277, p = 0.8706	F (1, 12) = 9.459,	F (1, 12) = 96.35,
		p = 0.0096	p < 0.0001
VEH:VEH vs. VEH:PA	p = 0.0102	p = 0.9360	p = < 0.0001
VEH:VEH vs. CORT:VEH	p = 0.3187	p = 0.7415	p = 0.0004
VEH:VEH vs. CORT:P A	p = 0.1687	p = 0.0003	p = < 0.0001
VEH:PA vs. CORT:VEH	p = 0.2987	p = 0.4143	p = 0.0878
VEH:PA vs. CORT:PA	p = 0.0003	p = 0.0001	p = 0.0755
CORT:VEH vs. CORT:PA	p = 0.0114	p = 0.0017	p = 0.0008