Table 1.

IOP-Lowering Medication Washout Schedule

Medication Class	Minimum Washout Period
Miotics and topical CAI	5 days ± 1 day
Alpha agonists	14 days ± 1 day
Beta antagonists, Prostaglandin analogues, Rho Kinase Inhibitors, Nitric Oxide	28 days ± 1 day
Combination drugs – Use longest washout period of the individual components	Up to 28 days ± 1 day

Abbreviations: IOP, Intraocular Pressure; CAI, Carbonic Anhydrase Inhibitor.