Comparison 1. DMPA vs NET‐EN.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Discontinuation rates	1		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
1.1 Discontinuation at 12 months	1	400	Risk Difference (M‐H, Random, 95% CI)	‐0.12 [‐0.21, ‐0.03]
1.2 discontinuation at 24 months	0	0	Risk Difference (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2 Reasons for discontinuation at 12 months	2		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
2.1 Accidental pregnancy	2	2776	Risk Difference (M‐H, Random, 95% CI)	‐0.00 [‐0.01, 0.00]
2.2 Amenorrhoea	2	2776	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.06, 0.09]
2.3 Bleeding problems	2	2776	Risk Difference (M‐H, Random, 95% CI)	‐0.01 [‐0.07, 0.05]
2.4 Other medical reasons	2	2776	Risk Difference (M‐H, Random, 95% CI)	‐0.02 [‐0.05, 0.01]
2.5 Personal reasons	2	2676	Risk Difference (M‐H, Random, 95% CI)	‐0.04 [‐0.07, ‐0.01]
3 Proportion of women with bleeding / spotting	2		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
3.1 Bleeding / spotting at 12 months	2	2577	Risk Difference (M‐H, Random, 95% CI)	0.02 [‐0.02, 0.06]
3.2 Bleeding / spotting at 24 months	1	1618	Risk Difference (M‐H, Random, 95% CI)	0.01 [‐0.00, 0.02]
4 Duration of bleeding and spotting episodes	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 duration of bleeding and spotting episodes at 12 months	1	1162	Mean Difference (IV, Random, 95% CI)	0.40 [‐0.43, 1.23]
4.2 Duration of bleeding and spotting episodes at 24 months	1	604	Mean Difference (IV, Random, 95% CI)	0.20 [‐0.51, 0.91]
5 Amenorrhoea	2		Risk Difference (M‐H, Random, 95% CI)	Subtotals only
5.1 Amenorrhoea at 12 months	2	1498	Risk Difference (M‐H, Random, 95% CI)	0.21 [0.08, 0.35]
5.2 Amenorrhoea at 24 months	1	698	Risk Difference (M‐H, Random, 95% CI)	0.21 [0.14, 0.29]
6 Mean increase in body weight	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Increase in weight at 12 months	2	1363	Mean Difference (IV, Random, 95% CI)	0.37 [‐0.33, 1.07]
6.2 Increase in weight at 24 months	1	604	Mean Difference (IV, Random, 95% CI)	0.0 [‐1.39, 1.39]
7 Mean decrease in blood pressure	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 Decrease in systolic blood pressure	2	1363	Mean Difference (IV, Random, 95% CI)	‐2.31 [‐8.79, 4.16]
7.2 Decrease in diastolic blood pressure	2	1363	Mean Difference (IV, Random, 95% CI)	‐0.58 [‐1.82, 0.66]