Table 1.
Clinicopathologic characteristics of the three HER2 statuses
| Clinicopathologic factor | Total | HER2 category |
p-value |
|||
|---|---|---|---|---|---|---|
| HER2-zero (n=4,649) | HER2-low (n=4,764) | HER2-positive (n=2,003) | Zero vs. low | Low vs. High | ||
| Age (yr) | ||||||
| < 60 | 7,624 | 3,133 (67.4) | 3,174 (66.6) | 1,317 (65.8) | 0.429 | 0.488 |
| ≥ 60 | 3,792 | 1,516 (32.6) | 1,590 (33.4) | 686 (34.2) | ||
| Specimen type | ||||||
| Needle biopsy | 4,674 | 1,894 (40.7) | 1,627 (34.2) | 1,153 (57.6) | < 0.001 | < 0.001 |
| Resection | 3,483 | 1,365 (29.4) | 1,563 (32.8) | 555 (27.7) | ||
| Needle biopsy and resection | 3,259 | 1,390 (29.9) | 1,574 (33.0) | 295 (14.7) | ||
| Histologic type | ||||||
| No special type | 10,319 | 4,093 (88.0) | 4,273 (89.7) | 1,953 (97.5) | 0.011 | < 0.001 |
| Special types | 1,097 | 556 (12.0) | 491 (10.3) | 50 (2.5) | ||
| ER status | ||||||
| Negative | 2,727 | 1,133 (24.4) | 611 (12.8) | 983 (49.1) | < 0.001 | < 0.001 |
| Positive | 8,689 | 3,516 (75.6) | 4,153 (87.2) | 1,020 (50.9) | ||
| PR status | ||||||
| Negative | 4,100 | 1,591 (34.2) | 1,203 (25.3) | 1,306 (65.1) | < 0.001 | < 0.001 |
| Positive | 7,316 | 3,058 (65.8) | 3,561 (74.7) | 697 (34.9) | ||
| Ki-67 index (%) | ||||||
| < 20 | 5,207 | 2,306 (49.6) | 2,586 (54.3) | 315 (15.7) | < 0.001 | < 0.001 |
| ≥ 20 | 6,209 | 2,343 (50.4) | 2,178 (45.7) | 1,688 (84.3) | ||
Values are presented as number (%). ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor.