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. 2024 Oct 7;15:1440958. doi: 10.3389/fphar.2024.1440958

FIGURE 12.

FIGURE 12

Comparison between the variance of PC1 and PC2 for Pim-1 dynamics in both the unliganded and inhibitor-bound states. Higher variance indicates higher structural dynamic freedom and flexibility and vice versa. Less structural flexibility is always associated with enzyme inhibition.