Figure 2.

Gene essentiality for cell lines with (A) APC T1396Nfs*3 mutation, (B) BRAF V600E mutation. On the left selected essential genes for cell lines with (A) APC T1396Nfs*3 mutation (chr5:112840254 G>GA) and (B) BRAF V600E mutation (chr7:140753336 A>T) are shown. The genes that should be considered crucial for cell proliferation are the ones with a mean difference of dependency score below -0.5 or above 0.5. A score below -0.5 indicates genes whose absence negatively affects cell proliferation, whereas a score above 0.5 indicates genes whose knock-out positively impacts cell proliferation. A pie chart on the right shows the number and proportion of CCL lineages with (A) APC T1396Nfs*3 and (B) BRAF V600E mutation.