FIG. 5.

NS5A-mediated reversal of the translation arrest phenotype observed in VVΔE3L-infected cells is independent of its ability to bind Grb2. Analyses of global protein synthesis in HeLa S3 cells pretreated with IFN-α/β and infected with a recombinant VV expressing a Grb2 binding-defective form of NS5A (VVPro3) were performed as described in the legend to Fig. 4. WT, wild type; p.i., postinfection.