Table 3.
Average causal effects of oral analgesic treatment on knee pain severity in participants with and without depressive symptoms from an IPTW-RWR SNMM
| Treatment | Pain assessment | Depressive symptoms, µ (95% CI) | No depressive symptoms, µ (95% CI) | Difference, µ (95% CI) |
|---|---|---|---|---|
| T1 | T2 | –0.10 (–9.94, 9.74) | 1.00 (–1.22, 3.21) | –1.10 (–11.19, 9.00) |
| T2 | T3 | –6.01 (–16.34, 4.32) | –0.77 (–3.24, 1.71) | –5.24 (–15.88, 5.39) |
| T3 | T4 | –16.67 (–26.33, –7.01) | –0.14 (–3.33, 3.06) | –16.53 (–26.75, –6.31) |
| T1–T2 | T3 | –5.38 (–20.62, 9.85) | –2.14 (–5.10, 0.83) | –3.25 (–18.62, 12.13) |
| T1–T3 | T4 | –2.76 (–24.11, 18.60) | –0.75 (–6.61, 5.11) | –2.01 (–24.08, 20.06) |
µ, causal mean difference; CI, confidence interval; IPTW-RWR SNMM, inverse-probability-of-treatment-weighted regression-with-residuals structural nested mean model; T1, Time 1; T2, Time 2; T3, Time 3; T4, Time 4; T1–T2, Time 1–Time 2; T1–T3, Time 1–Time 3.