Table 2.
Associations between cannabis use disorder and gastroschisis, Study of Outcomes in Mothers and Infants, 2007–19
| Gastroschisis |
RR (95% CI) | aRR a (95% CI) | aRR b (95% CI) | ||
|---|---|---|---|---|---|
| Cannabis use disorder | n | % | |||
| Full sample | |||||
| Yes (n = 50 435) | 72 | 0.14 | 2.5 (2.0–3.1) | 1.8 (1.4–2.3) | 1.3 (1.0–1.7) |
| No (n = 5 724 221) | 3317 | 0.06 | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) |
| Matched samplec | |||||
| Yes (n = 50 358) | 72 | 0.14 | 1.5 (1.1–2.0) | 1.5 (1.1–2.1) | |
| No (n = 100 716) | 97 | 0.10 | 1.0 (ref) | n/a | 1.0 (ref) |
aRR, adjusted risk ratio; CI, confidence interval; RR, risk ratio; .ref, reference value; n/a, not available.
Risk ratio adjusted for maternal age in years and race/ethnicity.
Risk ratio adjusted for maternal age in years, nulliparity, race/ethnicity, county urbanicity, payer, tobacco use, non-cannabis drug use, alcohol use disorder, maternal depression and maternal body mass index.
Matched cohort includes individual matching 1:2 (exposed to cannabis use disorder: unexposed to cannabis use disorder) on race (exact), birth year (exact to rounded year), maternal age (exact) and body mass index (exact category: underweight, normal, overweight, obese). Exposed births that were not matched to two unexposed births were excluded from the matched analyses.