Table 2.
Examples of the application of physical and chemical mutagenesis to improve production
| Strain | Method | Product | Improvement (-fold) | Ref. |
|---|---|---|---|---|
| Actinobacillus succinogenes | UV + NTG | Succinic acid | 1.85 | [163] |
| Propionibacterium acidipropionici | UV | Propionic acid | 1.25 | [164] |
| Bacillus velezensis | DES + NTG | Surfactin | 3.99 | [165] |
| Streptomyces virginiae | UV | Virginiamycin | 11.6 | [166] |
| Cordyceps kyushuensis | UV + HNO2 | 3β,7α,15α-Trihydroxy-5-androsten-17-one | 9.6 | [167] |
| Actinosynnema pretiosum | ARTP | Ansericin | 1.93 | [168] |