Table 1.
Factors Affecting Increases in IgG Antibody Levels Reacting to Fucosylated PfCSP Constructs
| Compared Conditions | Month 3/Month 0 | Month 8/Month 0 | ||
|---|---|---|---|---|
| Fold Difference (95% CI) | P Value | Fold Difference (95% CI) | P Value | |
| Antigen PfCSP full length | ||||
| Increase ratio estimate | 5079.1 (3833.1–6730.01) | <.0001*** | 829.2 (631.9–1088.2) | <.0001*** |
| Old/young | 0.65 (.34–1.25) | .20 | 0.61 (.32–1.14) | .12 |
| Female/male | 1.04 (.59–1.83) | .89 | 0.83 (.48–1.43) | .48 |
| P. falciparum not infected/infected | 1.96 (1.02–3.75) | .042* | 3.07 (1.64–5.73) | .0004** |
| Antigen PfCSP TSR | ||||
| Increase ratio estimate | 778.4 (625.7–968.3) | <.0001*** | 153.3 (128.0–183.5) | < .0001*** |
| Old/young | 0.56 (.34–.92) | .02* | 0.7 (.46–1.06) | .09 |
| Female/male | 1.1 (.71–1.7) | .68 | 0.85 (.59–1.21) | .36 |
| P. falciparum not infected/infected | 1.39 (.84–2.31) | .2 | 1.8 (1.18–2.72) | .005* |
Associations are reported as ratio estimates of month 3/month 0 or month 8/month 0 between groups of interest (compared conditions).
Abbreviations: CI, confidence interval; PfCSP, Plasmodium falciparum circumsporozoite protein; TSR, thrombospondin type-1 repeat.
* P < .05; **P < .01, ***P < .001.