7.

Trial sequential analysis of proportion of participants requiring hospital readmission 
 The diversity‐adjusted required information size (DARIS) was calculated to 21,030 participants, based on the proportion of participants in the control group with the outcome of 3.24%, a relative risk reduction of 20%, an alpha of 5%, a beta of 20%, and a diversity of 0%. To account for zero event groups, a continuity correction of 0.01 was used in the calculation of the cumulative Z‐curve (blue line). After accruing 290 participants in three trials, only 1.38% of the DARIS has been reached. Accordingly, the trial sequential analysis program does not show the required information size and the trial sequential monitoring boundaries. As shown, the conventional boundaries have also not been crossed.