Fig 1.

Dronedarone hydrochloride inhibited GC cell proliferation in vitro

(A) Chemical structure of Dronedarone hydrochloride. (B, C) The HGC27 (B) and AGS (C) cells were treated with DH at 0, 3.125, 6.25, 12.5, 25, and 50 μM for 24 and 48 h. The IC50 value of DH on gastric cancer cells. (D, E) The HGC27 (D) and AGS (E) cells were treated with DH for 24, 48, 72, and 96 h. The optical density (OD) value was evaluated by MTT assays and normalized to that of the control. (F) Gastric cancer cells were treated with various concentrations of DH (0, 0.5, 1, 2, and 4 μM) and measured at 7 days. (G) Gastric cancer cells were treated with various concentrations of DH (0, 0.5, 1, 2, and 4 μM) for 14 days, followed by crystal violet staining to monitor colony formation. Bar:50 μm. *p < 0.05, **p < 0.01, ***p < 0.001.