Fig. 7.

Dronedarone hydrochloride exerted the same anti-tumor activities as Dasatinib in vivo

(A) Tumor images of HSG288 xenografts in the 30 and 120 mg/kg DH and 13 mg/kg Dasatinib group. (B) and (C) The tumor volumes and weights of Vehicle, DH, and Dasatinib groups were measured. (D) Immunohistochemistry was used to analyze the protein levels of Ki67 in tumor tissues from treated or untreated groups of mice. *p < 0.05, **p < 0.01, ***p < 0.001. (E) The schematic drawing shows that DH inhibits GC growth by inhibiting the SRC/AKT pathway in vitro and in vivo.