FIG. 1.

Vaccine-elicited CTL responses. Mamu-A*01-positive monkeys were immunized at weeks 0, 4, and 21 with recombinant MVA constructs expressing SIV gag-pol and HIV-1 89.6 env. Vaccine-elicited CD8⁺ T-cell responses specific for the immunodominant SIV Gag p11C (CTPYDINQM) epitope (1, 24) were measured by tetramer staining of freshly isolated PBMC (3, 21). The percent CD3⁺ CD8⁺ T cells that bound the Mamu-A*01/p11C tetramer is shown. Arrows indicate times of immunization.