Apoptotic potentials of compounds 3e and 5a.
Compd no. | Caspase-3 | Caspase-8 | Bax | Bcl-2 | ||||
---|---|---|---|---|---|---|---|---|
Conc. (pg ml−1) | Fold change | Conc. (ng ml−1) | Fold change | Conc. (pg ml−1) | Fold change | Conc. (ng ml−1) | Fold reduction | |
3e | 587 ± 5 | 9 | 1.65 ± 0.20 | 19 | 316 ± 3 | 35 | 0.84 | 6 |
5a | 710 ± 6 | 11 | 1.70 ± 0.15 | 21 | 350 ± 3 | 39 | 0.62 | 8 |
Staurosporine | 465 ± 4 | 7 | 1.60 ± 0.10 | 18 | 288 ± 2 | 32 | 1.00 | 5 |
Control | 65 | 1 | 0.09 | 1 | 9 | 1 | 5.00 | 1 |