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. 2024 Oct 21;12:165. doi: 10.1186/s40478-024-01871-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — PDE1A upregulation in oligodendrocytes in HD (A) We identified upregulation of PDE1A across multiple clusters and regions. (B) Violin plots of expression of PDE1A in different regions and different clusters comparing HD and control donors. Stars represent adjusted p-values from MAST, *** p < 0.001. (C) Duplex RNAScope identification of PDE1A transcript (yellow) in MBP-expressing (red) oligodendroglia in human HD brain. DAPI-stained nuclei in blue. (D) BaseScope identification of PDE1A transcript (blue) in OLIG2 transcript-expressing (pink) oligodendroglia in human HD brain. (E) Dot plot showing expression of immune markers across microglial subclusters