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. 2024 Oct 21;12:165. doi: 10.1186/s40478-024-01871-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Molecular chaperone genes are upregulated across glial clusters in HD. A. Venn Diagram showing overlap of cluster markers between Astro_Thyme, Mglia_Violet and OPC_Pine. B. PPI network of shared cluster markers, coloured to denote genes belonging to one of the top 5 GO terms shown below. C-E. Expression of shared molecular chaperone genes in microglia, marking Mglia Violet (C), oligodendroglia, marking OPC Pine (D) and in astrocytes, marking Astro Thyme (E). Dot plots are colour coded according to chaperone family (key below). F-H. Volcano plots showing differentially expressed genes in Mglia Violet (F), OPC Pine (G) and Astro Thyme (H), labelling altered molecular chaperone genes and regions. Log2FC/p-values from MAST comparing HD and control within each cluster