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. 2024 Oct 21;12:165. doi: 10.1186/s40478-024-01871-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The molecular co-chaperone BAG3 is upregulated in HD microglia in a separate cohort. A-B. Double in situ hybridisation (A) on a separate human brain tissue cohort showing an increase (B) in microglia (ITGAM+, red) expressing BAG3, green. Arrow for double-positive cell. Plot shows median and range. (Welch Two Sample t-test, p-value = 0.023). C-D. Double in situ hybridisation (C) showing OPCs (PDGFRa+, red) expressing BAG3, green (D). Plot shows median and range (Wilcoxon rank sum test, p-value = 0.1). DAPI-stained nuclei coloured blue in images