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. 2024 Sep 30;24(4):e00631. doi: 10.34172/jrhs.2024.166

Table 5. Frequency of genotypes at SNPs rs11615 and rs3212986 in the ERCC1 gene in malignant patients based on sensitivity to cisplatin and carboplatin .

Total Frequency Responders Non-responders OR (95% CI) P value
PR+CR SD+PD
Genotype (rs11615)
Cisplatin
TT 2 1 1 1.001 (0.041, 24.547) 0.999
TC 19 6 13 2.166 (0.334, 14.057) 0.418
CC 6 3 3 Ref.
Carboplatin
TT 3 2 1 0.375 (0.022, 6.348) 0.497
TC 3 1 2 1.500 (0.089, 25.392) 0.779
CC 7 3 4 Ref.
Genotype (rs3212986)
Cisplatin
AA 5 3 2 0.667 (0.069, 6.409) 0.725
AC 14 3 11 3.667 (0.5557, 24.132) 0.177
CC 8 4 4 Ref.
Carboplatin
AA 4 1 3 3.000 (0.188, 47.963) 0.437
AC 3 2 1 0.500 (0.028, 8.952) 0.638
CC 6 3 3 Ref.

Note. SNP: single-nucleotide polymorphism; CI: Confidence interval; OR: Odds ratio. CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease.