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. 2024 Oct 21;28:338. doi: 10.1186/s13054-024-05108-6

Table 3.

High-cost user status post-discharge for those with and without sepsis during hospitalization

Variable Unweighted Weighted
Sepsis Non-Sepsis Measure of Association Sepsis Non-Sepsis Measure of Association
Total cohort
N = 79, 065 N = 847, 992 N = 888,513 N = 928,323
Death during follow-up, n (%) 30,158 (38.1%) 127,925 (15.1%) 25.60% 16.41%
High-Cost User (Top 5%) for any 90-day period after discharge from hospital, n (%) 35,419 (44.8%) 201,533 (23.8%) OR 2.60 (95% CI 2.56, 2.64) 36.51% 24.91% OR 1.73 (95% CI 1.70, 1.77)
High-Cost User (Top 1%) for any 90-day period after discharge from hospital, n (%) 10,082 (12.8%) 40,282 (4.8%) OR 2.93 (95% CI 2.86, 3.00) 9.96% 5.13% OR 2.05 (95% CI 1.99, 2.11)
Proportion of follow-up time as a High-Cost User (Top 5%), Mean ± SD, Median (IQR)

55.04% ± 39.22

52% (15–100)

27.33% ± 33.18

12% (3–39)

RR 2.01 (95% CI 2.01, 2.02) 42.27% 28.89% RR 1.46 (95% CI 1.45, 1.48)
Proportion of follow-up time as a High-Cost User (Top 1%), Mean ± SD, Median (IQR)

24.48 ± 33.11

8 (1–33)

10.09 ± 22.33

2 (0–7)

RR 2.43 (95% CI 2.42, 2.43) 18.15% 10.83% RR 1.68 (95% CI 1.65, 1.70)
Total length of follow-up (days), Mean ± SD, Median (IQR)

839.51 ± 437.37

934 (531 – 1,189)

1,016.06 ± 342.51

1,063 (854 – 1,281)

930.17 1006.42
Previously in top 10%
N = 75, 105 N = 782, 399 N = 821,753 N = 858,653
High-Cost User (Top 5%) for any 90-day period after discharge from hospital, n (%) 34,275 (45.6%) 194,921 (24.9%) OR 2.53 (95% CI 2.49, 2.57) 37.62% 26.07% OR 1.71 (95% CI 1.68, 1.74)
High-Cost User (Top 1%) for any 90-day period after discharge from hospital, n (%) 9,673 (12.9%) 38,716 (4.9%) OR 2.84 (95% CI 2.77, 2.91) 10.14% 5.33% OR 2.00 (95% CI 1.94, 2.07)
Proportion of follow-up time as a High-Cost User (Top 5%), Mean ± SD, Median (IQR)

56.40% ± 38.88

56% (17–100)

28.78% ± 33.62

13% (4–43)

RR 1.96 (95% CI 1.96, 1.96) 43.94% 30.37% RR 1.45 (95% CI 1.44, 1.46)
Proportion of follow-up time as a High-Cost User (Top 1%), Mean ± SD, Median (IQR)

25.04 ± 33.31

9 (2–35)

10.62 ± 22.84

2 (0–8)

RR 2.36 (95% CI 2.35, 2.36) 18.8% 11.38% RR 1.65 (95% CI 1.63, 1.68)
Not previously in top 10%
N = 3, 960 N = 65, 593 N = 66,961 N = 69,578
High-Cost User (Top 5%) for any 90-day period after discharge from hospital, n (%) l 1,144 (28.9%) 6,612 (10.1%) OR 3.62 (95% CI 3.37, 3.90) 20.89% 10.54% OR 2.24 (95% CI 2.04, 2.46)
High-Cost User (Top 1%) for any 90-day period after discharge from hospital, n (%) 409 (10.3%) 1,566 (2.4%) OR 4.71 (95% CI 4.20, 5.28) 7.13% 2.50% OR 2.99 (95% CI 2.60, 3.45)
Proportion of follow-up time as a High-Cost User (Top 5%), Mean ± SD, Median (IQR)

29.31% ± 36.79

10% (3–46)

10.05% ± 20.71

3% (0–8)

RR 2.92 (95% CI 2.90, 2.94) 19.39% 10.55% RR 1.84 (95% CI 1.74, 1.94)
Proportion of follow-up time as a High-Cost User (Top 1%), Mean ± SD, Median (IQR)

13.93 ± 26.96

3 (0–11)

3.79 ± 13.48

0 (0–2)

RR 3.68 (95% CI 3.64, 3.71) 9.13% 4.01% RR 2.28 (95% CI 2.10, 2.48)

OR Odds Ratio, RR Relative Rate, SD Standard Deviation, IQR Interquartile Range