Table 6.

Trial simulation illustrations

Scenario	Mean for treatment group 1	Mean for treatment group 2	P (reject dose 1)	P (reject dose 2)	P (reject any dose)
1	0	0	0.014	0.012	0.024
Assuming no futility stopping
2	0	0.65	0.013	0.979	0.979
3	0.325	0.65	0.265	0.959	0.967
4	0.65	0.65	0.882	0.877	0.993
Accounting for futility stopping
2	0	0.65	0.013	0.946	0.946
3	0.325	0.65	0.265	0.938	0.947
4	0.65	0.65	0.882	0.974	0.99