Table 2.
MS Registry/Data Source | DQI 1; Female Sex (%) | DQI 2; Median (IQR) Age at MS Onset | DQI 3; Median (IQR) Age at MS Diagnosis | ||||||
---|---|---|---|---|---|---|---|---|---|
Cladribine Cohort (N=2958) | Fingolimod Cohort (N=2111) | Total (N=5069) | Cladribine Cohort (N=2789) | Fingolimod Cohort (N=1964) | Total (N=4753) | Cladribine Cohort (N=2958) | Fingolimod Cohort (N=2111) | Total (N=5069) | |
Danish MS Registry | 66.3 | 67.6 | 67.2 | 30.0 (24.0, 37.0) | 30.0 (23.0, 37.0) | 30.0 (24.0, 37.0) | 32.0 (27.0, 40.0) | 33.0 (25.0, 41.0) | 33.0 (26.0, 41.0) |
Finnish MS Registry | 79.5 | 78.4 | 79.0 | 27.0 (22.0, 34.0) | 29.0 (22.0, 35.0) | 28.0 (22.0, 34.0) | 28.0 (24.0, 36.0) | 30.5 (24.0, 37.0) | 29.0 (24.0, 37.0) |
MSBase (multiple countries) | 73.3 | 70.8 | 72.0 | 31.0 (25.0, 40.0) | 29.0 (22.0, 35.0) | 30.0 (23.0, 37.0) | 34.0 (28.0, 43.0) | 31.0 (24.0, 38.0) | 33.0 (26.0, 40.0) |
MSDS3D (Germany) | 77.6 | 65.6 | 74.5 | 28.0 (23.0, 36.0) | 30.0 (23.0, 37.0) | 28.0 (23.0, 36.0) | 30.0 (24.0, 37.0) | 31.0 (24.0, 38.8) | 30.0 (24.0, 37.0) |
Norwegian MS Registry and Biobank | 69.4 | 67.1 | 68.9 | 32.0 (26.0, 40.0) | 33.0 (27.0, 40.0) | 32.0 (26.0, 40.0) | 35.0 (28.0, 43.0) | 36.0 (29.0, 43.0) | 35.0 (28.0, 43.0) |
Swedish MS Registry | 75.5 | 62.3 | 72.5 | 28.0 (23.0, 33.0) | 29.0 (24.0, 34.0) | 28.0 (23.0, 34.0) | 30.0 (25.0, 36.0) | 31.0 (27.0, 37.0) | 30.0 (26.0, 36.0) |
Swiss MS Cohort | 61.5 | 61.5 | 61.5 | 30.0 (26.0, 39.5) | 35.0 (27.0, 41.8) | 31.0 (26.0, 41.0) | 31.0 (26.0, 41.5) | 38.0 (27.0, 48.5) | 35.5 (27.0, 43.0) |
US Department of Defense | 82.2 | 77.6 | 80.1 | NA | 49.3 (37.8, 57.6) | 38.4 (30.4, 51.4) | 43.3 (33.8, 54.9) |
Notes: Cut-off date for most recent data quality indicators: November 1, 2022.
Abbreviations: DQI, data quality indicator; IQR, interquartile range; MS, multiple sclerosis; MSBase, MS Database; MSDS3D, MS Management System 3D; NA, not applicable.