Table 5.
Consistency DQIs in CLARION
| MS Registry/Data Source | DQI 1; No Visits During Past 1 Year—Total Population (N=4137) (%) | DQI 2; No Visits During Past 2 Years—Total Population (N=2899) (%) | DQI 3; Less Than 1 Visit/Year During Follow-Up—Total Populationa (N=2927) (%) | DQI 4; Average Number of Recorded Lymphocyte Count Measurements/Patient/Year—Cladribine Cohortb (N=1523) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | None | 0–1 | 1–2 | 2–3 | 3–4 | >4 | ||||
| Danish MS Registry | 16.6 | 3.5 | 33.4 | NA | ||||||
| Finnish MS Registry | 6.6 | 2.1 | NA | 2.7 (1.7) | 2.7 | 7.0 | 24.2 | 33.9 | 21.5 | 10.8 |
| MSBase (multiple countries) | 26.3 | 12.4 | 28.4 | 1.1 (1.7) | 42.4 | 29.2 | 9.5 | 5.2 | 6.6 | 7.2 |
| MSDS3D (Germany) | 6.8 | 0.0 | 4.5 | 0.3 (0.6) | 74.0 | 18.7 | 4.8 | 1.6 | 0.7 | 0.2 |
| Norwegian MS Registry and Biobank | 43.4 | 11.8 | NA | NA | ||||||
| Swedish MS Registry | 6.5 | 3.0 | 43.1 | 1.2 (1.0) | 29.3 | 18.4 | 32.8 | 15.5 | 2.3 | 1.7 |
| Swiss MS Cohort | 8.8 | 4.7 | 48.8 | 1.5 (1.9) | 44.2 | 32.6 | 11.6 | 4.7 | 4.7 | 2.3 |
| US Department of Defense | 7.0 | 2.8 | 0.0 | 1.1 (3.0) | 79.9c | 4.1 | 1.8 | 3.0 | 1.2 | 10.1 |
Notes: Cut-off date for most recent data quality indicators: November 1, 2022. aFinnish MS Registry and Norwegian MS Registry and Biobank did not contribute to DQI 3. bDanish MS Registry and Norwegian MS Registry and Biobank did not contribute to DQI 4 as these data sources did not collect data on lymphocyte counts. cUS Department of Defense did not include patients receiving care in the civilian sector—only those within US Department of Defense treatment facilities (~30% of the source population)—so the results can only be partially evaluated for DQI 4.
Abbreviations: DQI, data quality indicator; MS, multiple sclerosis; MSBase, MS Database; MSDS3D, MS Management System 3D; NA, not applicable; SD, standard deviation.