Table 6.
Accuracy DQIs in CLARION
| MS Registry/Data Source | DQI 1; Discrepant MS Onset Date (N=4635) (%)a | DQI 2; Discrepant MS Diagnosis Date (N=4661) (%)a | DQI 3; Discrepant MS Treatment Stop Dates (N=5069) (%) | DQI 4; Discrepant Treatment Stop Dates (Cladribine Cohort) (N=359) (%) | DQI 5; Discrepant Treatment Stop Dates (Fingolimod Cohort) (N=684) (%) | DQI 6; Discrepant Stop Date of AESI (N=29) (%)b | DQI 7; Duplicated MS Treatment Recordings (N=5069) (%) |
|---|---|---|---|---|---|---|---|
| Danish MS Registry | 1.9 | 0.0 | 2.0 | 12.5 | 3.0 | NA | 0.0 |
| Finnish MS Registry | 3.4 | 2.6 | 0.0 | 15.0 | 3.0 | NA | 5.0 |
| MSBase (multiple countries) | 0.6 | 0.0 | 0.2 | 0.0 | 2.8 | 0.0 | 0.0 |
| MSDS3D (Germany) | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 5.9 | 0.2 |
| Norwegian MS Registry and Biobank | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Swedish MS Registry | 5.2 | 4.8 | 2.7 | 26.7 | 0.0 | NA | 0.0 |
| Swiss MS Cohort | 0.0 | 0.0 | 1.1 | 0.0 | 10.0 | 0.0 | 0.0 |
| US Department of Defense | NA | NA | 15.2c | 14.8c | 19.5c | NA | 2.5 |
Notes: Cut-off date for most recent data quality indicators: November 1, 2022. aDQI 1 and DQI 2 were not evaluable for the US Department of Defense because MS onset date is not available in the data source and the available MS diagnosis date is not the exact MS diagnosis date but the earliest date when an MS diagnosis code was recorded. bDQI 6 was not evaluated for the Danish, Finnish, and Swedish MS Registries, and for the US Department of Defense. cDQI 3, DQI 4, and DQI 5 use a proxy definition for stop date equal to the start date plus number of days of supply, which can result in an overlap of MS treatments.
Abbreviations: AESI, adverse events of special interest; DQI, data quality indicator; MS, multiple sclerosis; MSBase, MS Database; MSDS3D, MS Management System 3D; NA, not applicable.