Table 1. Demographic and clinical characteristics of patients according to pretreatment HLA class I status. An adjusted p value of <0.05 was considered statistically significant.
| Characteristic | HLA-DEF (n=10) | HLA-PRO (n=14) | P value |
| Age (years)—median (range) | 66.5 (59.0–76.0) | 64.5 (41.0–74.0) | 1.000 |
| Sex—n (%) | 1.000 | ||
| Male | 8 (80.0) | 11 (78.6) | |
| Female | 2 (20.0) | 3 (21.4) | |
| Histology—n (%) | 0.590 | ||
| Adenocarcinoma | 5 (50.0) | 8 (57.1) | |
| Squamous | 5 (50.0) | 5 (35.7) | |
| No other specified | 0 (0.0) | 1 (7.1) | |
| Smoking status—n (%) | 1.000 | ||
| Former | 5 (50.0) | 6 (42.9) | |
| Current | 5 (50.0) | 8 (57.1) | |
| Packs-year—median (range) | 57.0 (24.0–111.0) | 50 (23.0–114.0) | 1.000 |
| Clinical response—n (%) | 0.673 | ||
| Partial | 6 (60.0) | 10 (71.4) | |
| Stable | 4 (40.0) | 4 (28.6) | |
| Surgery | 0.239 | ||
| Yes | 10 (100.0) | 11 (78.6) | |
| No | 0 (0.0) | 3 (21.4) | |
| Pathological response—n (%) | 0.670*, 1.000† | ||
| Complete | 5 (50.0) | 7 (50.0) | |
| Major | 2 (20.0) | 1 (7.1) | |
| Incomplete | 3 (30.0) | 3 (21.4) | |
*
Complete responses versus other.
†
Incomplete responses versus other.
HLAhuman leukocyte antigenHLA-DEFHLA-deficientHLA-PROHLA-proficient