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The expression changes and direct effects of AQPs in NSCLC
| AQP subtype | Expression in NSCLC | Direct effects |
|---|---|---|
| AQP1 | Up | Reduces intracellular oxygen levels and promotes MMP-2 and MMP-9 expression |
| AQP3 | Up | Glycerol entry into cells, leading to ATP generation, caspase 3 activation, and Wnt/GSK-3β/β-catenin |
| AQP4 | Up | Unknown |
| AQP5 | Up | Ser 156 phosphorylation |
