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. Author manuscript; available in PMC: 2024 Oct 21.
Published in final edited form as: Trends Cancer. 2019 Aug 16;5(10):579–582. doi: 10.1016/j.trecan.2019.07.010

Figure 1. Consequences of Disrupted Metabolism in Cancer-Associated Cachexia (CAC).

Figure 1.

(A) Depiction of muscle loss in CAC and potential recovery using therapies targeting metabolic processes through supplementation or stimulation of specific metabolic pathways. Tumors disrupt both metabolism and muscle regeneration, leading to a net loss of muscle mass. (B) Depiction of myogenesis showing activation of satellite cells (SCs), their self-renewal (SR), differentiation into myocytes, and myocyte fusion. We hypothesize that disrupted SC metabolism prevents normal progression through myogenesis.