Table 2. BLI susceptibility phenotypes for inhibitor resistance-assigned alleles.
Allele | Piperacillin-tazobactam (R/n, %R) | Amoxicillin-clavulanic acid (R/n, %R) | Mutation/s |
Exact matches to known alleles assigned as inhibitor resistant | |||
SHV-52 | 0/12 (100%) | 0/9 (100%) | 35Q, 69I |
SHV-107 | – | 2/2 (100%) | 235A |
Other alleles with mutations at Ambler site 69, 130, 234 or 235 | |||
SHV-2 +130G | 1/1 (100%) | 1/1 (100%) | 130G, 238S |
SHV-27* +69I | 0/1 (0%) | 0/1 (0%) | 69I |
SHV-27* +69L | 0/2 (0%) | 0/2 (0%) | 69L |
SHV-27* +130R | 0/1 (0%) | 0/1 (0%) | 130R |
SHV-110* +69I | 1/1 (100%) | 1/1 (100%) | 35Q, 69I, 156D |
SHV-164* +69I | 0/1 (0%) | 0/1 (0%) | 69I |
SHV-187* +69L† | 0/2 (0%) | 0/1 (0%) | 69L |
SHV-209* +69I | 2/2 (100%) | 1/1 (100%) | 35Q, 69I |
Exact matches to alleles reported in the literature as inhibitor resistant but assigned here as WT | |||
SHV-26 | 13/63 (20.6%) | 10/59 (16.9%) | – |
Novel alleles identified in this study have been highlighted with an ‘*’.
†SHV-187* +69L is SHV-132 in Kleborate v2.4.1.