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. 2024 Oct 21;10(10):001294. doi: 10.1099/mgen.0.001294

Table 2. BLI susceptibility phenotypes for inhibitor resistance-assigned alleles.

Allele Piperacillin-tazobactam (R/n, %R) Amoxicillin-clavulanic acid (R/n, %R) Mutation/s
Exact matches to known alleles assigned as inhibitor resistant
 SHV-52 0/12 (100%) 0/9 (100%) 35Q, 69I
 SHV-107 2/2 (100%) 235A
Other alleles with mutations at Ambler site 69, 130, 234 or 235
 SHV-2 +130G 1/1 (100%) 1/1 (100%) 130G, 238S
 SHV-27* +69I 0/1 (0%) 0/1 (0%) 69I
 SHV-27* +69L 0/2 (0%) 0/2 (0%) 69L
 SHV-27* +130R 0/1 (0%) 0/1 (0%) 130R
 SHV-110* +69I 1/1 (100%) 1/1 (100%) 35Q, 69I, 156D
 SHV-164* +69I 0/1 (0%) 0/1 (0%) 69I
 SHV-187* +69L† 0/2 (0%) 0/1 (0%) 69L
 SHV-209* +69I 2/2 (100%) 1/1 (100%) 35Q, 69I
Exact matches to alleles reported in the literature as inhibitor resistant but assigned here as WT
 SHV-26 13/63 (20.6%) 10/59 (16.9%)

Novel alleles identified in this study have been highlighted with an ‘*’.

†SHV-187* +69L is SHV-132 in Kleborate v2.4.1.