Fig. 1.

Structure of NLRX1. (A) Monomer of NLRX1, where cyan is cNLRX1, based on the crystal structure 3un9 and orange is nNLRX1, based on the AlphaFold model of NLRX1. (B) Top and side view of the hexamer model of NLRX1, where chains are coloured: A green, B aqua, C purple, D pink, E blue and F orange. (C) Dynamut1 output for NMA analysis of the monomer, dimer, and hexamer of NLRX1. (D) MTR output for NLRX1 were residues that were scored higher than 1 are coloured pink. (E) nNLRX1 (green) overlay with the NACHT domain of NLRP3 7vtq (blue). (F) nNLRX1 (green) overlay with the NACHT domain of NLRC4 4kxf (light blue).