Table 10.

The diagnostic performance of VCTE for liver fibrosis in patients with CHC

Reference	No. of patients	No. of studies	Significant fibrosis (≥F2)				Advanced fibrosis (≥F3)				Cirrhosis (F4)
			No. of patients (%)	AUC (95% CI)	Cutoff value	Sensitivity%/specificity%	No. of patients (%)	AUC (95% CI)	Cutoff value	Sensitivity%/specificity%	No. of patients (%)	AUC (95% CI)	Cutoff value	Sensitivity%/specificity%
Castéra et al. [175] (2005)	183	France	136 (74.3)	0.83 (0.76–0.88)	7.1	67.0/89.0	83 (45.3)	0.90 (0.85–0.94)	9.5	73.0/91.0	46 (25.1)	0.95 (0.91–0.98)	12.5	87.0/91.0
Ziol et al. [176] (2005)	327	France	163 (65.0)	0.79 (0.73–0.84)	8.7	56.0/91.0	76 (30.3)	0.91 (0.87–0.96)	9.6	86.0/85.0	49 (19.5)	0.97 (0.93–1.00)	14.5	86.0/96.0
Ganne-Carrié et al. [177] (2006)	298	France	-	-	-	-	-	-	-	-	30 (10.0)	-	10.4	88.0/85.0
Castéra et al. [178] (2009)	298	France	-	-	-	-	-	-	-	-	70 (23.5)	0.96 (0.93–0.98)	12.6	83.0/95.0
Degos et al. [108] (2010)	913	France	562 (61.6)	0.75 (0.71–0.78)	5.2	89.7/32.2	285 (31.2)	-	-	-	126 (13.8)	0.90 (0.86–0.93)	12.9	72.2/89.3
Fraquelli et al. [127] (2011)	453	Italy	197 (44.0)	-	8.8	81.0/77.0	88 (20.0)	-	-	-	44 (10.0)	-	14.6	100.0/88.0
Cardoso et al. [119] (2012)	363	France	197 (54.0)	0.86	7.1	68.0/89.0	87 (24.0)	-	9.5	68.0/92.0	31 (9.0)	0.94	12.5	84.0/94.0
Poynard et al. [165] (2012)	1,289	France	788 (61.0)	0.76 (0.73–0.79)	8.8	48.0/93.0	-	-	-	-	199 (15.0)	0.90 (0.87–0.92)	14.5	65.0/95.0
Zarski et al. [159] (2012)	382	France	200 (45.9)	0.82 (0.78–0.86)	5.2	96.6/34.8	132 (30.3)	-	-	-	61 (14.0)	0.93 (0.89–0.96)	12.9	76.8/89.6
Schwabl et al. [179] (2015)	226	Austria	210 (92.9)	0.85	7.2	-	159 (70.3)	-	-	-	124 (54.8)	0.85	14.5	-
Seo et al. [180] (2015)	349	Korea	303 (86.8)	0.82 (0.77–0.86)	6.8	67.0/86.4	118 (33.8)	0.86 (0.82–0.90)	8.6	79.8/83.1	22 (6.3)	0.91 (0.86–0.95)	14.5	81.8/89.0

CHC, chronic hepatitis C; AUC, area under the curve; CI, confidence interval; kPa, kilopascal.