Table 18.
Reference | No. of patients | Nation | Test | Significant fibrosis (≥F2) |
Advanced fibrosis (≥F3) |
Cirrhosis (F4) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of patients (%) | AUC (95% CI) | Cutoff value | Sensitivity%/specificity% | No. of patients (%) | AUC (95% CI) | Cutoff value | Sensitivity%/specificity% | No. of patients (%) | AUC (95% CI) | Cutoff value | Sensitivity%/specificity% | ||||
Zhang et al. [305] (2015) | 99 | China | pSWE | 60 (60.6) | 0.85 (0.77-0.92) | 1.27 m/s | 77.0/85.0 | 25 (25.2) | 0.88 (0.79–0.96) | 1.4 | 84.0/82.0 | 9 (9.1) | 0.89 (0.82–0.96) | 1.65 m/s | 89.0/84.0 |
Kiani et al. [319] (2016) | 82 | France | pSWE | 34 (41.5) | 0.87 | 1.63 m/s | 82.4/83.3 | 17 (20.7) | 0.86 | 1.84 | 82.4/78.5 | 13 (15.9) | 0.89 | 1.94 m/s | 92.3/81.6 |
Cho et al. [320] (2020) | 251 | Korea | pSWE | 204 (81.3) | 0.93 (0.89–0.97) | 1.46 m/s | 84.8/89.4 | 175 (69.7) | 0.90 (0.86–0.95) | 1.47 | 90.9/76.3 | 144 (57.3) | 0.91 (0.87–0.95) | 1.66 m/s | 97.2/74.8 |
Thiele et al. [312] (2016) | 199 | Denmark | 2D-SWE | 84* (42.2) | 0.94 (0.91–0.97) | 10.2 kPa | 82.0/93.0 | - | - | - | - | 36† (18.1) | 0.95 (0.92–0.98) | 16.4 kPa | 94.0/91.0 |
Thiele et al. [303] (2018) | 289 | Denmark | 2D-SWE | 146 (50.5) | 0.88 (0.84–0.92) | - | - | 66 (23.0) | 0.97 (0.94–0.99) | 16.4 | 90.0/96.0 | 49 (17.0) | 0.97 (0.94–0.99) | - | - |
ALD, Alcohol-related liver disease; pSWE, point shear wave elastography; 2D-SWE, 2D shear wave elastography. AUC, area under the curve; CI, confidence interval; kPa, kilopascal.
Ishak ≥3.
Ishak ≥5.