Table 7.

Diagnostic performance of MRE for liver fibrosis in patients with CHB

Cross-sectional study
Reference	No. of patients	Nation	Significant fibrosis (≥F2)				Advanced fibrosis (≥F3)				Cirrhosis (F4)
			No. of patients (%)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%	No. of patients (%)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%	No. of patients (%)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%
Lee et al. [149] (2014)	170	Korea	151 (88.8)	0.99 (0.97–0.99)	2.7	95.4/95.6	125 (73.5)	0.99 (0.97–0.99)	3.0	95.2/93.8	81 (47.6)	0.99 (0.97–0.99)	3.9	95.1/94.5
Venkatesh et al. [150] (2014)	63	Singapore	39 (61.9)	0.99 (0.94–1.00)	3.2	97.4/100	29 (46.0)	0.99 (0.93–1.00)	3.7	100/94.1	21 (33.3)	0.98 (0.92–1.00)	4.3	100/95.2
Chang et al. [151] (2016)	281	Korea	257 (91.5)	0.97 (0.95–0.99)	2.6	90.7/96.0	213 (75.8)	0.95 (0.92–0.97)	2.9	89.2/88.2	139 (49.5)	0.92 (0.89–0.95)	3.7	83.5/90.7
Park et al. [152] (2019)	63	Korea	44 (69.8)	0.91 (0.81–0.97)	2.5	81.8/94.7	30 (47.6)	-	-	-	16 (25.4)	0.89 (0.79–0.96)	3.5	88.9/97.8
Meta-analysis
Reference	No. of patients	No. of studies	Significant fibrosis (≥F2)				Advanced fibrosis (≥F3)				Cirrhosis (F4)
			No. of studies (patients)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%	No. of studies (patients)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%	No. of studies (patients)	AUC (95% CI)	Cutoff value (kPa)	Sensitivity%/specificity%
Xiao et al. [153] (2017)	1,470	9	9 (1,470)	0.98	3.0	92.8/93.7	9 (1,470)	0.97	3.6	89.6/93.2	9 (1,470)	0.97	4.6	89.5/92.0
Dong et al. [143] (2021)	1,134	9	9 (716)	0.97 (0.95–0.98)	3.1	89.3/91.7	8 (493)	0.97 (0.96–0.99)	4.0	88.6/91.1	8 (274)	0.97 (0.97–0.98)	4.7	91.4/92.4

MRE, magnetic resonance elastography; CHB, chronic hepatitis B; AUC, area under the curve; CI, confidence interval; kPa, kilopascal.