Table 1.

Pooled prevalence of liver fibrosis among the general population stratified by noninvasive tests and geographical regions

Noninvasive fibrosis tests	Stage of liver fibrosis	Number of studies	Region	Number of patients	Pooled prevalence (95% confidence interval) (%)	I2 (%) (P)
Fibrosis-4 index	Advanced liver fibrosis (≥F3)	13	Overall	509,191	2.3 (1.2–3.7)	99.8 (<0.001)
		3	Region of the Americas	21,552	4.3 (1.7–7.9)	N/A
		6	European Region	200,332	2.2 (0.8–4.3)	99.8 (<0.001)
		4	Western Pacific Region	287,307	1.3 (0.2–3.2)	99.9 (<0.001)
Vibration-controlled transient elastography	Significant liver fibrosis (≥F2)	22	Overall	56,969	7.3 (5.9–8.8)	97.4 (<0.001)
		3	Region of the Americas	8,587	10.7 (8.7–12.9)	N/A
		11	European Region	41,049	6.1 (4.5–7.9)	97.9 (<0.001)
		5	Western Pacific Region	2,381	7.1 (3.2–12.2)	94.4 (<0.001)
		1	South-East Asian Region	901	14.4 (12.2–16.9)	N/A
		1	African Region	72	11.1 (4.9–20.7)	N/A
		1	Mixed	3,979	5.6 (4.9–6.4)	N/A
	Advanced liver fibrosis (≥F3)	15	Overall	45,395	3.5 (2.7–4.5)	95.4 (<0.001)
		4	Region of the Americas	8,886	5.8 (4.7–7.0)	73.6 (0.01)
		6	European Region	31,411	3.1 (2.4–3.9)	92.0 (<0.001)
		4	Western Pacific Region	4,197	2.4 (1.1–4.2)	88.1 (<0.001)
		1	South-East Asian Region	901	2.2 (1.4–3.4)	N/A
	Liver cirrhosis (F4)	14	Overall	38,232	1.2 (0.8–1.8)	94.7 (<0.001)
		3	Region of the Americas	8,587	2.2 (1.4–3.1)	N/A
		6	European Region	20,216	1.1 (0.5–2.1)	95.7 (<0.001)
		2	Western Pacific Region	2,889	0.2 (0.1–0.5)	N/A
		2	South-East Asian Region	2,561	1.4 (0.9–1.9)	N/A
		1	Mixed	3,979	1.2 (0.9–1.6)	N/A

N/A, not available.