Table 2.
The diagnostic performance of vibration-controlled transient elastography and FIB-4 in chronic hepatitis C patients with sustained virological response
| Test | Time of measurement | Cutoff | Number of studies | Number of patients | Number of HCCs | AUC | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| VCTE | Pre-treatment | Total (9.2–27.8 kPa) | 8 | 4,871 | 239 | 0.73 | 65.7 (45.5–0.81) | 69.5 (56.8–79.8) | 2.22 (1.65–2.99) | 0.48 (0.28–0.85) |
| 9.2–13 kPa | 5 | 3,354 | 153 | 0.79 | 75.1 (61.9–84.9) | 71.7 (50.3–86.3) | 2.67 (1.85–3.86) | 0.39 (0.29–0.51) | ||
| After SVR | Total (8.4–11 kPa) | 6 | 3,840 | 171 | 0.77 | 76.6 (69.3–82.6) | 63.9 (51.5–74.7) | 2.20 (1.62–3.00) | 0.37 (0.28–0.49) | |
| FIB–4 | Pre-treatment | Total (1.45–5) | 15 | 154,408 | 5,386 | 0.72 | 73.4 (66.1–79.6) | 60.5 (52.7–67.8) | 1.88 (1.67–2.11) | 0.50 (0.45–0.56) |
| 3.25 | 13 | 86,435 | 4,330 | 0.73 | 70.9 (62.4–78.1) | 64.9 (55.5–73.3) | 2.05 (1.73–2.43) | 0.48 (0.42–0.55) | ||
| 3.25–5.0 | 5a | 40,534 | 3,339 | 0.66 | 73.3 (63.2–81.5) | 52.4 (42.3–62.3) | 1.56 (1.34–1.81) | 0.50 (0.40–0.63) | ||
| After SVR | Total (2.73–3.7) | 9 | 14,757 | 605 | 0.71 | 61.6 (55.0–67.8) | 73.7 (66.9–79.6) | 2.34 (1.98–2.77) | 0.55 (0.50–0.60) | |
| 3.25 | 7 | 13,019 | 480 | 0.70 | 57.9 (50.2–65.2) | 75.4 (68.0–81.6) | 2.37 (1.89–2.85) | 0.58 (0.51–0.65) |
HCC, hepatocellular carcinoma; AUC, area under the receiver operating characteristic; CI, confidence interval; FIB-4, fibrosis-4 index; SVR, sustained virological response; VCTE, vibration-controlled transient elastography; kPa, kilopascal.
a
Studies including only patients with liver cirrhosis.