Table 2.
Univariate and multivariate analysis for OS
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age, years (≥65/<65) | 0.25 | 0.03–1.90 | 0.179 | |||
| Sex (male/female) | 0.41 | 0.11–1.49 | 0.177 | |||
| Child-Pugh class (B/A) | 1.10 | 0.14–8.42 | 0.927 | |||
| Baseline ALT, IU/L (≥40/<40) | 1.07 | 0.37–3.09 | 0.899 | |||
| Baseline ALB, g/L (≥35/<35) | 0.61 | 0.17–2.18 | 0.445 | |||
| Baseline NLR (≥2.6/<2.6) | 5.09 | 1.41–18.41 | 0.013 | 5.53 | 1.36–22.52 | 0.017 |
| Baseline AFP, ng/mL (≥400/<400) | 8.34 | 1.09–63.87 | 0.041 | 6.14 | 0.79–47.80 | 0.083 |
| Preoperative AFP, ng/mL (≥400/<400) | 1.87 | 0.58–6.01 | 0.294 | |||
| Macrovascular invasion (yes/no) | 1.59 | 0.49–5.11 | 0.436 | |||
| Maximum tumor size, cm (≥10/<10) | 1.55 | 0.53–4.52 | 0.420 | |||
| Tumor number (multiple/single) | 1.00 | 0.28–3.58 | 0.995 | |||
| Hepatectomy (major/minor) | 0.66 | 0.23–1.93 | 0.453 | |||
| MVI (yes/no) | 4.38 | 1.37–14.02 | 0.013 | 1.03 | 0.27–2.03 | 0.962 |
| Satellite nodules (yes/no) | 1.68 | 0.55–5.09 | 0.361 | |||
| MPR (yes/no) | 0.05 | 0.01–0.23 | <0.001 | 0.07 | 0.01–0.31 | 0.001 |
HR, hazard ratio; CI, confidence interval; ALT, alanine transaminase; ALB, albumin; NLR, neutrophil-to-lymphocyte ratio; AFP, alpha-fetoprotein.