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Pedigree of the family suspected of Li-Fraumeni syndrome. The red arrow indicates the proband, the gray filling indicates individuals with cancer, and the red outline indicates individuals enrolled in this study. Disease names are followed by age at diagnosis. LC, Lung cancer; OS, Osteosarcoma; CM, Cerebrovascular Malformation; BC, Breast Cancer; AC, Astrocytoma; MB, Medulloblastoma.
