FIGURE 2.

IMT, DV2-103, and IMT isomer 1 are γ-secretase modulators. (A) N2a695 cells incubated with IMT, DV2-103 and IMT isomer 1 lower levels of Aβ40 and 42 more than Aβ38, especially at a drug concentration of 5 μM, as measured by ELISA. Means differ significantly for IMT and DV2-103 compared to DMSO controls, N = 3 × 3. Data for Isomer 1 are from a representative sample. Differences between means for (A) are analyzed by One-way Anova for IMT and DV2-103 treated cells. Differences among means comparing 5 μM IMT and DMSO controls (B, C) are analyzed by Student’s T test (S.E.M.).