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. 2024 Oct 8;12:1381205. doi: 10.3389/fchem.2024.1381205

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Copyright © 2024 Netzer, Sinha, Ghias, Chang, Gindinova, Mui, Seo and Sinha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IMT isomer 1 (IMTi-1) and its analogs 1d, 1f and 1p lower BACE and γ-secretase cleavage of APP and lower levels of Aβ in N2a cells transiently transfected with APP 695 (left graph) or APP C99 (right graph): (A) full length APP695 (APP-FL) or (B) APP C99 (β-CTF). (C) Percentage of viable wild-type (WT) N2a cells upon treatment with IMT isomers 1, cpd. 1d, cpd. 1f and cpd. 1p compared to DMSO control under the same conditions used to test Aβ production. (D) Effects of IMTi-1 on Abl1 kinase in vitro. (E) Brain and plasma concentrations of IMTi-1 and cpd. 1f in 2 months old WT mice 4 h after i. p. injection of 50 mg/kg of each drug. Data for A-C are from representative samples.