SCHEME 1.

Design of IMTi-1 – 3 and analogs. (A) Shown are hypothetical fragmentation of IMT involving (a) C-N bond or (b, c) C-C bond cleavage giving fragments I-VI, and re-assembly of these fragments to afford IMTi-1 – 3. Note: fragment II is common for both IMTi-1 and 3, and III for IMTi-2 and 3. Key: Scissor sign, site of C-C or C-N bond cleavage for fragmentation; double arrow, C-C or C-N bond connection for re-assembly of the molecules. (B) General structure of IMT analogs described previously (Sun et al., 2019) and of IMTi-1’s and 2’s designed here.