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The predicted quinidine concentrations for 5,000 simulated horses based on Monte Carlo simulations after PO administration of quinidine sulfate dihydrate 22 mg/kg (18.24 mg/kg as QND base) q 2 h (left) and q 6 h (right). The predicted concentrations for 10, 50% (median), and 90% of the populations are indicated using red, black and blue lines, respectively. The green area indicates the therapeutic range (2.0–3.8 μg/mL).
