Figure 9.

The predicted quinidine concentration for 5,000 simulated horses based on Monte Carlo simulations after administration of quinidine sulfate dihydrate 15 mg/kg (12.44 mg/kg as QND base) as loading dose and 3 mg/kg (2.49 mg/kg as QND base) q 2 h three times as maintenance dose on first day, 30 mg/kg (24.87 mg/kg as QND base) as loading dose and 6.5 mg/kg (4.97 mg/kg as QND base) q 2 h three times on second day, and 40 mg/kg (33.16 mg/kg as QND base) as loading dose and 9 mg/kg (7.46 mg/kg as QND base) q 2 h three times on third day. The predicted concentrations for 10, 50% (median), and 90% of the populations are indicated using red, black and blue lines, respectively. The green area indicates the therapeutic range (2.0–3.8 μg/mL).