Table 2.
List of DAPs for olive baboons (aged vs. young). Accession number, protein name, gene name, p-value and log2 Fold Change are provided. Proteins are ordered by increasing p-value. Top 5 DAPs are highlighted in bold
| Accession number | Protein name | Gene name | p-value | Log2 aged baboon |
|---|---|---|---|---|
| A0A096NQN2 | Pentraxin | APCS | < 0.0001 | 2.99 |
| A0A096NEV9 | Ig-like domain-containing protein | IGHA | < 0.0001 | 1.84 |
| A0A2I3M4W7 | Dematin actin binding protein | DMTN | 0.00013 | 1.41 |
| A0A2I3MAI1 | Transketolase | TKT | 0.00023 | -0.63 |
| A0A096N1Y1 | Clusterin | CLU | 0.00029 | 0.787 |
| A0A2I3MM55 | Joining chain of multimeric IgA and IgM | JCHAIN | 0.00038 | 1.78 |
| A0A2I3MW37 | Paraspeckle component 1 | PSPC1 | 0.0004 | -1.91 |
| A0A096P228 | Complement C4-A | C4A | 0.00042 | 1.29 |
| A0A096NJK4 | Serpin family A member 3 | SERPINA3 | 0.00043 | 1.38 |
| A0A2I3MWE6 | Ig-like domain-containing protein | IGHM | 0.00062 | 1.35 |
| A0A2I3LD62 | Transcription elongation regulator 1 | TCERG1 | 0.00068 | -1.37 |
| A0A2I3N2B9 | IGv domain-containing protein | 0.00071 | 1.25 | |
| A0A096NIN4 | Cell division cycle 5 like | CDC5L | 0.00071 | 1.17 |
| A0A096MM00 | Non-POU domain containing octamer binding | NONO | 0.00075 | -1.8 |
| A0A096NN03 | HDGF like 3 | HDGFL3 | 0.00084 | 2.74 |
| A0A2I3NEJ3 | Laminin subunit beta 2 | LAMB2 | 0.0009 | 0.731 |
| A0A096NUT9 | RALY heterogeneous nuclear ribonucleoprotein | RALY | 0.0011 | -0.892 |
| A0A2I3LWK4 | Immunoglobulin heavy variable 3–72 | IGHV3-72 | 0.0012 | 1.46 |
| A0A0A0MUA3 | Heterogeneous nuclear ribonucleoprotein M | HNRNPM | 0.0012 | -1.43 |
| A0A096MPI8 | Filaggrin family member 2 | FLG2 | 0.0013 | 2.12 |
| A0A096NSI5 | Calretinin | CALB2 | 0.0015 | 2.43 |
| A0A096N317 | Splicing factor, proline- and glutamine-rich | SFPQ | 0.0015 | -1.15 |
| A0A2I3MJZ3 | Actinin alpha 2 | ACTN2 | 0.0015 | -1.44 |
| A0A2I3MDY2 | Myocardin related transcription factor B | MRTFB | 0.0016 | -1.48 |
| A0A0A0MU60 | Aldehyde dehydrogenase family 16 member A1 | ALDH16A1 | 0.0017 | 1.93 |
| A0A2I3NGY5 | Ig-like domain-containing protein | 0.0017 | 1.16 | |
| A0A2I3NC97 | Ig-like domain-containing protein | 0.0017 | 1 | |
| A0A2I3MP06 | Tropomyosin 4 | TPM4 | 0.0017 | 0.55 |
| A0A2I3M158 | Ubiquitin recognition factor in ER associated degradation 1 | UFD1 | 0.0017 | -1.87 |
| A0A0A0MU58 | Actinin alpha 4 | ACTN4 | 0.002 | -1.56 |
| A0A2I3LZX6 | Uncharacterized protein | HNRNPH2 | 0.0021 | -1.79 |
| P05770 | Apolipoprotein E | APOE | 0.0023 | 1.39 |
| A0A2I3M2P0 | Heterogeneous nuclear ribonucleoprotein H1 | HNRNPH1 | 0.0023 | -1.65 |
| A0A096N1T1 | Histidine rich glycoprotein | HRG | 0.0024 | 0.801 |
| A0A2I3MT71 | Complement C1r subcomponent like | C1RL | 0.0025 | 1.36 |
| A0A2I3LTI2 | General vesicular transport factor p115 | USO1 | 0.0028 | -1.17 |
| A0A096NKK0 | Serpin family B member 9 | SERPINB9 | 0.0029 | -1.07 |
| A0A2I3MTT7 | Ribosomal protein L22 | RPL22 | 0.0029 | -1.69 |
| A0A096NK84 | Cysteine rich protein 1 | CRIP1 | 0.0032 | 1.95 |
| A0A2I3LU29 | PC4 and SFRS1 interacting protein 1 | PSIP1 | 0.0032 | 1.09 |
| A0A096P0K3 | Spectrin alpha, non-erythrocytic 1 | SPTAN1 | 0.0033 | -0.771 |
| A0A2I3MTE9 | Ig-like domain-containing protein | 0.0035 | 1.36 | |
| A0A2I3M360 | Inter-alpha-trypsin inhibitor heavy chain 5 | ITIH5 | 0.0036 | -0.971 |
| A0A2I3LFB9 | Zinc finger protein 207 | ZNF207 | 0.0036 | -0.985 |
| A0A2I3M0F1 | Lymphocyte cytosolic protein 2 | LCP2 | 0.0037 | 1.65 |
| A0A2I3MCZ4 | Ig-like domain-containing protein | 0.0044 | 0.832 | |
| A0A2I3LP09 | Shisa family member 7 | SHISA7 | 0.0048 | -0.728 |
| A0A0A0MU78 | Shisa family member 7 | SHISA7 | 0.0048 | -0.749 |
| A0A096N709 | Transaldolase | TALDO1 | 0.0048 | -0.771 |
| A0A096N345 | Hemopexin | HPX | 0.0049 | 0.689 |
| A0A2I3LXY2 | Non-specific serine/threonine protein kinase | SLK | 0.005 | -1 |
| A0A2I3LHU4 | HLA class II histocompatibility antigen, DR beta 3 chain | 0.0054 | 4.55 | |
| A0A096N4D7 | Ro60, Y RNA binding protein | RO60 | 0.0057 | -0.627 |
| A0A2I3LMG7 | Spectrin alpha, non-erythrocytic 1 | SPTAN1 | 0.0057 | -0.978 |
| A0A096NFT8 | MARCKS like 1 | MARCKSL1 | 0.0059 | 1.75 |
| A0A2I3N4Y0 | Calumenin | CALU | 0.006 | 1.65 |
| A0A2I3LNH3 | KH-type splicing regulatory protein | KHSRP | 0.006 | -0.719 |
| A0A096P4D3 | Multimerin 2 | MMRN2 | 0.0061 | 0.851 |
| A0A2I3LJS5 | Myosin heavy chain 10 | MYH10 | 0.0062 | -0.923 |
| A0A2I3NAA8 | Apoptosis inducing factor mitochondria associated 1 | AIFM1 | 0.0062 | -1.3 |
| A0A096N7V3 | Complement component 4 binding protein alpha | C4BPA | 0.0063 | 1.33 |
| A0A2I3M1T5 | Adenosine deaminase RNA specific | ADAR | 0.0066 | -0.934 |
| A0A2I3MSR7 | Tropomyosin 3 | TPM3 | 0.0067 | 0.647 |
| A0A2I3MIX0 | DNA damage-binding protein 1 | DDB1 | 0.0067 | -0.627 |
| A0A096MYE5 | Myosin regulatory light chain 12A | MYL12A | 0.0068 | 0.914 |
| A0A096NL32 | Enoyl-CoA delta isomerase 1 | ECI1 | 0.0068 | -2.39 |
| A0A2I3MZY8 | Aldo–keto reductase family 1 member C1 homolog | AKR1C1 | 0.0069 | -1.09 |
| A0A2I3MSB6 | Cytochrome b-c1 complex subunit 7 | UQCRB | 0.0075 | 3.13 |
| A0A2I3LPQ6 | CXADR Ig-like cell adhesion molecule | CXADR | 0.0076 | 1.06 |
| A0A096MWL2 | Syndecan binding protein | SDCBP | 0.0076 | 0.622 |
| A0A2I3M6Q6 | Nuclear mitotic apparatus protein 1 | NUMA1 | 0.0077 | -0.665 |
| A0A2I3LE24 | PTPRF interacting protein alpha 1 | PPFIA1 | 0.0077 | -0.696 |
| A0A2I3LH89 | Ig-like domain-containing protein | 0.0078 | 1.12 | |
| A0A096P0S3 | V-type proton ATPase subunit G | ATP6V1G1 | 0.0079 | 3.14 |
| A0A096NBS2 | Selenocysteine lyase | SCLY | 0.0085 | -0.526 |
| A0A096NZE2 | Small RNA binding exonuclease protection factor La | SSB | 0.0086 | -1.61 |
| A0A096NFU9 | Ig-like domain-containing protein | 0.0088 | 2.54 | |
| A0A096NV22 | Endoplasmic reticulum oxidoreductase 1 alpha | ERO1A | 0.009 | 0.597 |
| A0A096NRJ1 | CD59 glycoprotein | 0.009 | 0.56 | |
| A0A096P5I3 | Keratin 27 | KRT27 | 0.0092 | 1.13 |
| A0A2I3LH21 | Dynein cytoplasmic 1 intermediate chain 2 | DYNC1I2 | 0.0096 | -1.36 |
| A0A2I3M314 | QKI, KH domain containing RNA binding | QKI | 0.0098 | -1.41 |
| A0A2I3N4K0 | G3BP stress granule assembly factor 1 | G3BP1 | 0.01 | 1.28 |
| A0A096N6A0 | Myristoylated alanine rich protein kinase C substrate | MARCKS | 0.01 | 0.988 |
| A0A2I3N200 | Heterogeneous nuclear ribonucleoprotein D | HNRNPD | 0.01 | -0.604 |
| A0A096P2E8 | Nuclear cap-binding protein subunit 3 | NCBP3 | 0.011 | 1.44 |
| A0A096NM11 | Ig-like domain-containing protein | 0.011 | 1.35 | |
| A0A2I3MSK0 | Nucleoporin 153 | NUP153 | 0.011 | -1.4 |
| A0A2I3LID9 | RNA binding protein fox-1 homolog 1 | RBFOX1 | 0.011 | -1.42 |
| B0VYX8 | Cytochrome c oxidase subunit 5A, mitochondrial | COX5A | 0.012 | 0.938 |
| A0A2I3LRD7 | Laminin subunit alpha 3 | LAMA3 | 0.012 | 0.93 |
| A0A096NT92 | Galectin-3-binding protein | LGALS3BP | 0.012 | 0.553 |
| A0A096N5V4 | Chitinase-3-like protein 1 | CHI3L1 | 0.012 | -1.2 |
| A0A2I3MZJ5 | Talin 1 | TLN1 | 0.013 | -0.643 |
| A0A2I3M4M4 | Cell division cycle and apoptosis regulator 1 | CCAR1 | 0.013 | -1.34 |
| A0A2I3MIF7 | Filamin-C | FLNC | 0.014 | -1.84 |
| A0A0A0MWY7 | Splicing factor U2AF subunit | U2AF2 | 0.014 | -1.89 |
| A0A096MQP5 | Ig-like domain-containing protein | 0.015 | 1.57 | |
| A0A096NVY7 | BH3-interacting domain death agonist | BID | 0.015 | 0.966 |
| A0A096NEY1 | Choline-specific glycerophosphodiester phosphodiesterase | ENPP6 | 0.015 | -1.75 |
| A0A096NKT3 | Desmoplakin | DSP | 0.016 | 0.618 |
| A0A096MNQ3 | C-X-C motif chemokine | PPBP | 0.016 | -0.575 |
| A0A2I3MIV3 | Actinin alpha 1 | ACTN1 | 0.016 | -1.13 |
| A0A0A0MXC4 | Transcription elongation factor SPT5 | SUPT5H | 0.016 | -1.23 |
| A0A096MPU5 | Serpin B6-like | SERPINB6 | 0.016 | -1.4 |
| A0A2I3LKR9 | Septin | SEPTIN11 | 0.016 | -1.43 |
| A0A2I3M614 | Keratin, type I cuticular Ha3-I | KRT33A | 0.017 | 1.53 |
| A0A0A0MWZ3 | Calponin | CNN1 | 0.017 | 1.03 |
| A0A2I3LNI7 | Acidic nuclear phosphoprotein 32 family member A | ANP32A | 0.017 | 1.02 |
| A0A096N402 | Cathepsin D | CTSD | 0.017 | 0.545 |
| A0A096N9Y0 | Clathrin interactor 1 | CLINT1 | 0.017 | -0.729 |
| A0A2I3M3R5 | Prefoldin subunit 4 | PFDN4 | 0.018 | 1.82 |
| A0A096NUK6 | Myosin light chain 9 | MYL9 | 0.018 | 0.841 |
| A0A2I3MGL1 | Solute carrier family 12 member 2 | SLC12A2 | 0.018 | 0.783 |
| A0A2I3NB00 | EPS8 like 2 | EPS8L2 | 0.018 | -0.57 |
| A0A0A0MUI0 | Tripartite motif containing 28 | TRIM28 | 0.018 | -0.869 |
| A0A2I3N473 | 60S ribosomal protein L8 | RPL8 | 0.018 | -1.88 |
| A0A2I3MQY3 | Immunoglobulin kappa variable 4–1 | IGKV4-1 | 0.019 | 0.84 |
| A0A096N1J7 | Apolipoprotein D | APOD | 0.019 | 0.617 |
| A0A096NFB0 | All-trans-retinol dehydrogenase [NAD( +)] ADH1B | ADH7 | 0.019 | -0.898 |
| A0A096MWK3 | Filamin A | FLNA | 0.019 | -0.938 |
| A0A096N6E3 | Hyaluronan and proteoglycan link protein 1 | HAPLN1 | 0.019 | -2.56 |
| A0A2I3LE14 | Keratin 10 | KRT10 | 0.02 | 1.03 |
| A0A096N0H9 | Adducin 2 | ADD2 | 0.02 | 0.514 |
| A0A096N1Y4 | PKSO | ADH7 | 0.02 | -0.795 |
| A0A2I3MZ49 | Serine and arginine rich splicing factor 5 | SRSF5 | 0.021 | 2.9 |
| A0A2I3MDH7 | Serine and arginine rich splicing factor 10 | SRSF10 | 0.021 | 1.68 |
| A0A096N0E7 | Marginal zone B and B1 cell specific protein | MZB1 | 0.021 | 1.35 |
| A0A096N6Z6 | Poly(rC) binding protein 1 | PCBP1 | 0.021 | -1.09 |
| A0A096NA79 | Transcription factor Sp1 | SP1 | 0.021 | -1.52 |
| A0A096MU45 | Ig-like domain-containing protein | 0.022 | 1.1 | |
| A0A2I3MM66 |
Protein S100 TYMP |
S100A11 | 0.022 | 0.506 |
| A0A096MN47 | Keratin 77 | KRT77 | 0.023 | 1.08 |
| A0A2I3LS05 | 2-phospho-D-glycerate hydro-lyase | ENO2 | 0.023 | -0.942 |
| A0A096MVE7 | RWD domain containing 1 | RWDD1 | 0.024 | 1.3 |
| A0A2I3N9B6 | Host cell factor C1 | HCFC1 | 0.024 | -0.707 |
| A0A2I3LXU6 | Ribosomal protein | RPL10A | 0.024 | -1.16 |
| A0A2I3MXU2 | Synaptotagmin binding cytoplasmic RNA interacting protein | SYNCRIP | 0.024 | -1.19 |
| A0A2I3M825 | Zinc finger RNA binding protein | ZFR | 0.024 | -1.31 |
| A0A2I3M8L5 | Synaptopodin 2 | SYNPO2 | 0.025 | 1.58 |
| A0A2I3M1I3 | Latent transforming growth factor beta binding protein 1 | LTBP1 | 0.025 | 0.972 |
| A0A096MV46 | Immunoglobulin kappa variable 6D-41 (non-functional) | IGKV6D-41 | 0.025 | 0.764 |
| A0A096NR90 | Ig-like domain-containing protein | 0.026 | 1.04 | |
| A0A2I3MML7 | Ig-like domain-containing protein | 0.026 | 0.842 | |
| A0A2I3LKS6 | Tight junction protein 1 | TJP1 | 0.026 | -0.559 |
| A0A096P3B1 | Aldo–keto reductase family 1 member C1 homolog | AKR1C1 | 0.026 | -1.05 |
| A0A2I3MLZ3 | Seryl-tRNA synthetase | SARS1 | 0.026 | -1.3 |
| A0A096N2S9 | F-spondin | SPON1 | 0.026 | -1.47 |
| A0A096MYJ5 | Copine 3 | CPNE3 | 0.027 | 0.539 |
| A0A096NAR9 | Spectrin beta chain | SPTBN1 | 0.028 | -0.624 |
| A0A096N5A4 | HtrA serine peptidase 2 | HTRA2 | 0.029 | 0.528 |
| A0A2I3LNW4 | Tight junction protein 2 | TJP2 | 0.029 | -0.729 |
| A0A096MNW7 | Adipocyte-type fatty acid-binding protein | FABP4 | 0.029 | -1.23 |
| A0A2I3N8Y4 | 3-beta-hydroxysterol Delta (14)-reductase | LBR | 0.031 | 1.79 |
| A0A2I3LFF0 | Keratin 17 | KRT17 | 0.031 | 1.67 |
| A0A096P1P8 | Frataxin, mitochondrial | FXN | 0.031 | 0.969 |
| A0A2I3LJL3 | Non-specific protein-tyrosine kinase | PTK2 | 0.031 | -0.525 |
| A0A2I3MM96 | Heat shock protein family A (Hsp70) member 5 | HSPA5 | 0.031 | -1.87 |
| A9L8U0 | Hemoglobin subunit theta 1 | HBQ1 | 0.032 | 1.51 |
| A0A2I3N512 | 4-trimethylaminobutyraldehyde dehydrogenase | ALDH9A1 | 0.032 | 0.727 |
| A0A2I3LIT0 | GLI pathogenesis related 2 | GLIPR2 | 0.032 | -0.513 |
| A0A096N1H4 | Splicing factor 3b subunit 1 | SF3B1 | 0.032 | -0.9 |
| A0A0A0MWU1 | Bromodomain containing 4 | BRD4 | 0.032 | -0.965 |
| A0A096N5N8 | Uncharacterized protein | HNRNPA3 | 0.032 | -2.26 |
| A0A096P131 | Acidic nuclear phosphoprotein 32 family member B | ANP32B | 0.034 | 0.83 |
| A0A096P5P4 | Junction plakoglobin | JUP | 0.034 | 0.652 |
| A0A096ML84 | Uncharacterized protein | HNRNPA3 | 0.034 | -1.94 |
| A9X1C4 | Huntingtin interacting protein K | HYPK | 0.035 | 1.06 |
| A0A096NPT5 | Heterogeneous nuclear ribonucleoprotein A3 | HNRNPA3 | 0.036 | -1.15 |
| A0A096MXZ5 | Serine and arginine rich splicing factor 9 | SRSF9 | 0.037 | 0.767 |
| A0A096NZG7 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | BST1 | 0.037 | 0.509 |
| A0A2I3M5I3 | Small nuclear ribonucleoprotein U5 subunit 200 | SNRNP200 | 0.037 | -0.749 |
| A0A2I3LIJ2 | Septin | SEPTIN7 | 0.037 | -0.873 |
| A0A096N4V8 | Keratin, type II cytoskeletal 6C | KRT5 | 0.039 | 1.18 |
| A0A2I3M017 | Parvalbumin | PVALB | 0.039 | 0.543 |
| A0A096MV19 | Thyroid hormone receptor associated protein 3 | THRAP3 | 0.039 | -0.742 |
| A0A096P4S7 | Serine/arginine-rich splicing factor 1 | SRSF1 | 0.04 | 0.871 |
| A0A2I3N6J2 | Tensin 1 | TNS1 | 0.041 | -0.64 |
| A0A096MQV4 | Lamin A/C | LMNA | 0.041 | -1.16 |
| A0A2I3MZ19 | RNA binding protein, mRNA processing factor | RBPMS | 0.042 | 1.23 |
| A0A096NDH2 | CSD domain-containing protein | YBX1 | 0.042 | 1.16 |
| A0A2I3LXT9 | PDS5 cohesin associated factor B | PDS5B | 0.042 | -0.97 |
| A0A096N233 | Taxilin alpha | TXLNA | 0.043 | 4.23 |
| A0A096NUU1 | Charged multivesicular body protein 4B | CHMP4B | 0.043 | 1 |
| A0A2I3MLK1 | Pinin | PNN | 0.044 | -1.18 |
| A0A2I3M0D0 | Zinc finger CCCH-type containing 11A | ZC3H11A | 0.044 | -1.45 |
| A0A2I3N574 | RRM domain-containing protein | RBMX | 0.045 | 1.21 |
| A0A2I3M706 | Ig-like domain-containing protein | 0.045 | 0.556 | |
| A0A096P534 | Phenazine biosynthesis like protein domain containing | PBLD | 0.045 | -1.28 |
| A0A096NPS7 | All-trans-retinol dehydrogenase [NAD( +)] ADH1B | ADH7 | 0.045 | -1.32 |
| A0A2I3LFE6 | Four and a half LIM domains 1 | FHL1 | 0.046 | -1.39 |
| A0A096NWE1 | Crystallin beta-gamma domain containing 3 | CRYBG3 | 0.046 | -2.76 |
| A4K2N4 | Syndecan | SDC4 | 0.047 | 1.13 |
| A0A2I3LK27 | Moesin | MSN | 0.047 | -0.711 |
| A0A096NZQ0 | Ferredoxin 1 | FDX1 | 0.048 | 0.929 |
| A0A2I3MLU1 | CDKN2A interacting protein | CDKN2AIP | 0.048 | -1.8 |
| A0A096ML57 | Acyl-CoA dehydrogenase family member 8 | ACAD8 | 0.049 | 0.877 |
| A0A096NAU0 | Cytokeratin-1 | KRT1 | 0.049 | 0.8 |
| A0A2I3N6R9 | Heterogeneous nuclear ribonucleoprotein R | HNRNPR | 0.049 | -0.897 |
| A0A2I3LZ61 | Vitelline membrane outer layer 1 homolog | VMO1 | 0.049 | -0.906 |
| A0A096N6J5 | Calcium-activated chloride channel regulator 1 | CLCA1 | 0.049 | -1.57 |
| A0A2I3LNR5 | Amyloid beta precursor like protein 2 | APLP2 | 0.05 | 1.59 |
| A0A2I3MNR7 | Helix-destabilizing protein | HNRNPA1 | 0.05 | -1.35 |